Pittsburgh Pirates
| Date | Transaction |
| 06/27/2012 | Shairon Martis Traded to Minnesota Twins; for future considerations |
| 06/26/2012 | Doug Slaten Designated for Assignment |
| 06/26/2012 | Daniel Moskos Designated for Assignment |
| 06/26/2012 | Eric Fryer Purchased From Minors |
| 06/26/2012 | Matt Hague Sent to Minors |
| 06/25/2012 | Jeff Karstens Recalled From Minors Rehab |
| 06/25/2012 | Bryan Morris Sent to Minors |
| 06/24/2012 | Charlie Morton Transferred to 60-Day DL; Right elbow inflammation |
| 06/24/2012 | Drew Sutton Acquired Off Waivers from Tampa Bay Rays |
| 06/24/2012 | Jordy Mercer Sent to Minors |
| 06/24/2012 | Bryan Morris Called Up from Minors |
| 06/21/2012 | Daniel McCutchen Recalled From Minors Rehab |
| 06/21/2012 | Daniel McCutchen Sent to Minors |
| 06/19/2012 | Jeff Karstens Sent to Minors for Rehabilitation |
| 06/14/2012 | Daniel McCutchen Sent to Minors for Rehabilitation |
| 06/10/2012 | Miguel Perez Signed to a Minor League Contract |
| 06/08/2012 | Jeff Karstens Recalled From Minors Rehab |
| 06/06/2012 | Chris Leroux Sent to Minors for Rehabilitation |
| 06/05/2012 | Alex Presley Called Up from Minors |
| 06/05/2012 | Gorkys Hernandez Sent to Minors |
| 06/02/2012 | Nate McLouth Cleared Waivers and Became a Free Agent |
| 06/01/2012 | Juan Cruz Reinstated From Restricted List |
| 05/31/2012 | Nate McLouth Released |
| 05/29/2012 | Yamaico Navarro Sent to Minors |
| 05/29/2012 | Jordy Mercer Called Up from Minors |
| 05/28/2012 | Juan Cruz Placed on Restricted List |
| 05/28/2012 | Doug Slaten Purchased From Minors |
| 05/25/2012 | Nate McLouth Designated for Assignment |
| 05/25/2012 | Matt Hague Called Up from Minors |
| 05/23/2012 | Jason Grilli Reinstated from Bereavement/Family Medical Emergency List |
| 05/22/2012 | Jeff Locke Sent to Minors |
| 05/21/2012 | Jeff Karstens Sent to Minors for Rehabilitation |
| 05/21/2012 | Drew Sutton Traded to Tampa Bay Rays; for future considerations |
| 05/20/2012 | Jason Grilli Placed on Bereavement/Family Medical Emergency List |
| 05/20/2012 | Drew Sutton Traded from Atlanta Braves; for cash considerations |
| 05/20/2012 | Jeff Locke Called Up from Minors |
| 05/18/2012 | Evan Meek Sent to Minors |
| 05/18/2012 | Gorkys Hernandez Called Up from Minors |
| 05/16/2012 | Evan Meek Called Up from Minors |
| 05/16/2012 | Alex Presley Sent to Minors |
| 05/13/2012 | Joel Hanrahan Reinstated from Bereavement/Family Medical Emergency List |
| 05/11/2012 | Jeff Larish Traded from Boston Red Sox; for cash considerations |
| 05/10/2012 | Joel Hanrahan Placed on Bereavement/Family Medical Emergency List |
| 05/10/2012 | Daniel McCutchen Called Up from Minors |
| 05/01/2012 | Jared Hughes Called Up from Minors |
| 04/30/2012 | Evan Meek Sent to Minors |
| 04/25/2012 | Jared Hughes Called Up from Minors; recalled as 26th roster player |
| 04/25/2012 | Jared Hughes Sent to Minors |
| 04/21/2012 | A.J. Burnett Recalled From Minors Rehab |
| 04/21/2012 | Jared Hughes Sent to Minors |
| 04/18/2012 | Brad Lincoln Called Up from Minors |
| 04/14/2012 | Charlie Morton Recalled From Minors Rehab |
| 04/14/2012 | Matt Hague Sent to Minors |
| 04/11/2012 | Rick VandenHurk Signed to a Minor League Contract |
| 04/09/2012 | Charlie Morton Sent to Minors for Rehabilitation |
| 04/07/2012 | Brian Tallet Traded to San Diego Padres; for future considerations |
| 04/06/2012 | A.J. Burnett Sent to Minors for Rehabilitation |
| 04/04/2012 | Juan Cruz Purchased From Minors |
| 04/03/2012 | Daniel Moskos Sent to Minors |
| 04/01/2012 | Daniel McCutchen Sent to Minors |
| 04/01/2012 | Brad Lincoln Sent to Minors |
| 03/30/2012 | Ryota Igarashi Traded to Toronto Blue Jays; for future considerations |
| 03/24/2012 | Jordy Mercer Sent to Minors |
| 03/18/2012 | Starling Marte Sent to Minors |
| 03/18/2012 | Gorkys Hernandez Sent to Minors |
| 03/18/2012 | Bryan Morris Sent to Minors |
| 03/15/2012 | Rudy Owens Sent to Minors |
| 03/15/2012 | Chase d'Arnaud Sent to Minors |
| 03/15/2012 | Jeff Locke Sent to Minors |
| 03/05/2012 | Andrew McCutchen Signed; six-year extension |
| 03/05/2012 | Michael Dubee Signed to a Minor League Contract |
| 02/19/2012 | A.J. Burnett Traded from New York Yankees; for P Diego Moreno & OF Exicardo Cayones |
| 02/16/2012 | Garrett Jones Signed; loses arbitration |
| 02/16/2012 | Casey McGehee Signed; avoids arbitration |
| 02/03/2012 | Brian Tallet Signed to a Minor League Contract |
| 02/01/2012 | Juan Cruz Signed to a Minor League Contract |
| 01/28/2012 | Daniel Cabrera Signed to a Minor League Contract |
| 01/17/2012 | Jeff Karstens Signed; avoids arbitration |
| 01/17/2012 | Evan Meek Signed; avoids arbitration |
| 01/16/2012 | Joel Hanrahan Signed; avoids arbitration |
| 01/16/2012 | Charlie Morton Signed; avoids arbitration |
| 01/13/2012 | Chris Resop Signed; avoids arbitration |
| 01/11/2012 | Doug Slaten Signed to a Minor League Contract |
| 01/04/2012 | Logan Kensing Signed to a Minor League Contract |
| 01/04/2012 | Jo-Jo Reyes Signed to a Minor League Contract |
| 12/21/2011 | Anderson Hernandez Signed to a Minor League Contract |
| 12/20/2011 | Jeff Clement Signed to a Minor League Contract |
| 12/20/2011 | Ryota Igarashi Signed to a Minor League Contract |
| 12/12/2011 | Jason Grilli Signed; avoids arbitration |
| 12/12/2011 | Jose Veras Traded to Milwaukee Brewers; for 3B Casey McGehee |
| 12/12/2011 | Ross Ohlendorf Cleared Waivers and Became a Free Agent |
| 12/12/2011 | Casey McGehee Traded from Milwaukee Brewers; for RHP Jose Veras |
| 12/12/2011 | Jason Jaramillo Free Agent - No Contract Offer; non-tendered |
| 12/12/2011 | Pedro Ciriaco Free Agent - No Contract Offer; non-tendered |
| 12/12/2011 | Jeremy Hefner Acquired Off Waivers to New York Mets |
| 12/09/2011 | Erik Bedard Signed as Free Agent; one-year contract |
| 12/09/2011 | Nate McLouth Signed as Free Agent; one-year contract |
| 12/09/2011 | Pedro Ciriaco Designated for Assignment |
| 12/09/2011 | Jeremy Hefner Designated for Assignment |
| 12/08/2011 | Aaron Poreda Drafted Via Rule 5; Triple-A phase |
| 12/08/2011 | Gustavo Nunez Drafted Via Rule 5 |
| 12/07/2011 | Ross Ohlendorf Released |
| 12/07/2011 | Jose Morales Signed to a Minor League Contract |
| 12/07/2011 | Jason Jaramillo Designated for Assignment |
| 12/07/2011 | Yamaico Navarro Traded from Kansas City Royals; for P Brooks Pounders & INF Diego Goris |
| 11/30/2011 | Xavier Paul Cleared Waivers and Became a Free Agent |
| 11/29/2011 | Nick Evans Signed to a Minor League Contract |
| 11/28/2011 | Xavier Paul Released |
| 11/23/2011 | Eric Fryer Outrighted to Minors |
| 11/23/2011 | Brian Jeroloman Acquired Off Waivers to Toronto Blue Jays |
| 11/22/2011 | Jake Fox Signed to a Minor League Contract |
| 11/22/2011 | Brandon Boggs Signed to a Minor League Contract |
| 11/22/2011 | Shairon Martis Signed to a Minor League Contract |
| 11/21/2011 | Clint Barmes Signed as Free Agent; two-year contract |
| 11/21/2011 | Matt Pagnozzi Refused Minor League Assignment - Free Agent |
| 11/21/2011 | Brian Jeroloman Designated for Assignment |
| 11/18/2011 | Xavier Paul Designated for Assignment |
| 11/18/2011 | Matt Pagnozzi Outrighted to Minors |
| 11/18/2011 | Rudy Owens Purchased From Minors |
| 11/18/2011 | Eric Fryer Designated for Assignment |
| 11/18/2011 | Brian Jeroloman Acquired Off Waivers from Toronto Blue Jays |
| 11/18/2011 | Starling Marte Purchased From Minors |
| 11/18/2011 | Matt Hague Purchased From Minors |
| 11/18/2011 | Jeremy Hefner Acquired Off Waivers from San Diego Padres |
| 11/18/2011 | Jordy Mercer Purchased From Minors |
| 11/11/2011 | Rod Barajas Signed as Free Agent; one-year contract |
| 11/06/2011 | Michael Ryan Signed to a Minor League Contract |
| 11/04/2011 | Steve Pearce Refused Minor League Assignment - Free Agent |
| 11/02/2011 | Brian Burres Refused Minor League Assignment - Free Agent |