Buffalo Bills
2012
| Date | Transaction |
| 06/20/2012 | Reggie Corner - Signed / unrestricted free agent to Jaguars |
| 06/02/2012 | Paul Madsen - Acquired from waivers to Ravens |
| 05/31/2012 | Garrick Williams - Cut from Bills |
| 05/31/2012 | Isaiah Green - Signed to Bills |
| 05/30/2012 | Derek Session - Signed to Bills |
| 05/30/2012 | Paul Madsen - Cut from Bills |
| 05/18/2012 | Cordy Glenn - Signed / draft choice to Bills - Four-year contract (through 2015) |
| 05/17/2012 | Stephon Gilmore - Signed / draft choice to Bills - Four-year contract (fifth-year option) |
| 05/14/2012 | Ian Wild - Cut from Bills |
| 05/14/2012 | James Carmon - Signed to Bills |
| 05/14/2012 | Dorin Dickerson - Signed to Bills |
| 05/14/2012 | Brandon Coutu - Signed to Jaguars |
| 05/14/2012 | Nick Saenz - Signed to Bills |
| 05/14/2012 | Aaron Corp - Cut from Bills |
| 05/11/2012 | Vince Young - Signed to Bills - One-year contract (through 2012) |
| 05/10/2012 | Zebrie Sanders - Signed / draft choice to Bills - Four-year contract (through 2015) |
| 05/10/2012 | Nigel Bradham - Signed / draft choice to Bills - Four-year contract (through 2015) |
| 05/10/2012 | John Potter - Signed / draft choice to Bills - Four-year contract (through 2015) |
| 05/10/2012 | Drayton Florence - Signed to Broncos - Two-year contract (through 2013) |
| 05/10/2012 | Mark Asper - Signed / draft choice to Bills - Four-year contract (through 2015) |
| 05/10/2012 | Tank Carder - Signed / draft choice to Bills - Four-year contract (through 2015) |
| 05/10/2012 | Ron Brooks - Signed / draft choice to Bills - Four-year contract (through 2015) |
| 05/07/2012 | Fred Jackson - Re-signed to Bills - Two-year extension (through 2014) |
| 05/04/2012 | Drayton Florence - Cut from Bills |
| 05/02/2012 | Ed Wang - Signed to Raiders |
| 04/30/2012 | Ian Wild - Signed to Bills |
| 04/30/2012 | Garrick Williams - Signed to Bills |
| 04/30/2012 | Delano Howell - Signed to Bills |
| 04/30/2012 | Nick Sukay - Signed to Bills |
| 04/30/2012 | Paul Madsen - Signed to Bills |
| 04/30/2012 | Shawn Powell - Signed to Bills |
| 04/30/2012 | David Snow - Signed to Bills |
| 04/30/2012 | Aaron Corp - Signed to Bills |
| 04/30/2012 | Chris Douglas - Signed to Bills |
| 04/30/2012 | Cris Hill - Signed to Bills |
| 04/23/2012 | Chad Rinehart - Re-signed / restricted free agent to Bills |
| 04/23/2012 | Kraig Urbik - Re-signed / restricted free agent to Bills |
| 04/04/2012 | Demetress Bell - Signed / unrestricted free agent to Eagles - Five-year contract (through 2016) |
| 04/03/2012 | Roscoe Parrish - Signed / unrestricted free agent to Chargers - One-year contract (through 2012) |
| 03/24/2012 | Tashard Choice - Re-signed / unrestricted free agent for Bills |
| 03/21/2012 | Bryan Scott - Re-signed / unrestricted free agent for Bills |
| 03/21/2012 | Mark Anderson - Signed / unrestricted free agent to Bills - Four-year contract (through 2015) |
| 03/19/2012 | Derek Hagan - Re-signed / unrestricted free agent for Bills |
| 03/15/2012 | Mario Williams - Signed / unrestricted free agent to Bills - Six-year contract (through 2017) |
| 03/13/2012 | Derek Hagan - Declared free agent |
| 03/13/2012 | Brandon Coutu - Declared free agent |
| 03/13/2012 | Bryan Scott - Declared free agent |
| 03/13/2012 | Demetress Bell - Declared free agent |
| 03/13/2012 | Dave Rayner - Declared free agent |
| 03/13/2012 | Tashard Choice - Declared free agent |
| 03/13/2012 | Reggie Corner - Declared free agent |
| 03/13/2012 | Bruce Hall - Declared free agent |
| 03/13/2012 | Andra Davis - Declared free agent |
| 03/13/2012 | Roscoe Parrish - Declared free agent |
| 03/13/2012 | Chad Rinehart - |
| 03/13/2012 | Kraig Urbik - |
| 03/13/2012 | Reggie Torbor - Declared free agent |
| 03/09/2012 | Kirk Morrison - Re-signed to Bills - Two-year extension (through 2013) |
| 03/08/2012 | Scott Chandler - Re-signed to Bills - Two-year extension (through 2013) |
| 03/07/2012 | Ruvell Martin - Re-signed to Bills - One-year extension (through 2012) |
| 03/05/2012 | Stevie Johnson - Re-signed to Bills - Five-year extension (through 2016) |